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The study of carotenoids dates back to the early nineteenth century, when carotenoids were first found and extracted from paprika (in 1817), saffron (in 1818), annatto (in 1825), carrots (in 1831), and autumn leaves (in 1837) [5,6]
This is backed by clinical data: a 2006 study found that taking 2x3 g MSM daily for 12 weeks led to noticeable reductions in pain and improvements in mobility and quality of life
The data are cross-sectional, though we predict that follow-up would likely increase the clinical utility of ECL-GADA [13, 14]
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