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In a study on diabetic mice, carnosine supplementation increased plasma levels of carnosine 20-fold, reduced triglyceride levels by 23%, and increased stability of atherosclerotic lesions (Brown 2014)

The reduction of human RNR, which was suggested to follow mechanism (ii) 46 , therefore needs to be analyzed and monothiol mechanism (iii) should be also considered

The formation of reactive oxygen species (ROS) has been recognized to be a contributor to PD, and oxidative stress is a major part in the pathophysiology of the disease
