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The results for NAC and carbocisteine led to a statement in the 2017 Global initiative for Chronic Obstructive Lung Disease (GOLD) guidelines listing these antioxidant/mucolytic drugs as an additional therapy to consider in the treatment of COPD

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Although ATP depletion may disrupt a series of intracellular homeostatic processes and lead to uncontrolled cell death, the nature of tumor necrosis remains ill-defined, and the molecular mechanisms underlying its development remain unclear

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These small differences in efficacy of BLX2477 may be explained by the 3-log higher IC 50 of BLX2477 for free versus PE-esterified eicosatetraenoic acid (ETE) (Supplemental Figure 3)

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