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is also relevant in neurological and psychiatric diseases, as the brain is considered especially vulnerable to oxidative damage for several reasons, including its high oxygen utilization and hence generation of ROS, its modest antioxidant defenses, its lipid-rich neuronal circuitry that provides ready substrates for oxidation, the redox potential of certain neurotransmitters, and the presence of metals such as iron and copper essential for redox catalysis [4]

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4-Hydroxynonenal Induces a Cellular Redox Status-Related Activation of the Caspase Cascade for Apoptotic Cell Death