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This stage is typically characterized by a loss of immune tolerance ( Figure 3 ) ( Figure 3 Understanding the detailed pathophysiology of RA is critical for developing targeted therapies to manage and potentially alter disease progression

10.1016/j.arbres.2021.05.002 160 PicadoC.Roca-FerrerJ

In response, recent years have seen the emergence of innovative bioengineering approaches aimed at optimizing stem cell delivery, their functionality within target tissues, and their longevity
