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Notably, 4-HNE can activate the PPAR pathway, suppressing PGC-1-mediated mitochondrial biogenesis and reducing local ATP supply at synapses, thereby impairing plasticity mechanisms such as LTP (194)
For the control experiment, 4T1 cells were first incubated with ALDH inhibitor DEAB for 4 h, and then incubated with PS-CHO@ATRA-SS-ATRA + L at a gradient concentration (0 - 20 g/mL) for 48 h
Seth D, Hess DT, Hausladen A, Wang L, Wang Y-J, Stamler JS
Yuan, X., Mitchell, B
