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For instance, pyruvate oxidation in the taurine-deficient heart decreases, as an increased NADH/NAD + ratio stops the activity of pyruvate dehydrogenase and results in a deficiency in pyruvate due to the substantial conversion of pyruvate to lactate [38,51]

Cell Physiol Biochem 2016;39:7180

Importantly, these phenotypes contrast with the non-inducible liver-specific Gclc KO mouse strain ( Gclc f/f Albumin-Cre), which develops liver failure and dies shortly after birth 30
