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This study found lower ACC Glu and GABA in the SZ group and higher ACC lactate in the longer illness group, which are consistent with neuroimaging, post-mortem, and behavioral research implicating ACC abnormalities in SZ ( There was a trend for lower ACC GABA in SZ compared to HC which was related to lower level of function as a whole, and greater negative symptom severity in the longer illness group
doi: 10.1016/j.bbadis.2014.11.016
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