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However, more research is needed to definitively determine the long-term effects and safety of SAG supplementation [11]

Conversely, since the LDH isoform derived from the LDHB gene is primarily responsible for the oxidation of lactate to pyruvate the high level of LDHB expression in -cells ensures that the bulk of lactate generated from pyruvate via the actions of LDHA derived LDH is rapidly oxidized back to pyruvate

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