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It thereby supports both innate and adaptive immunity 3
found SUMO-specific proteases 1 (SENP1) expression was decreased in IH-treated microglia, which reduced the level of Target of Myb 1 (TOM1) and peroxisome proliferator-activated receptor (PPAR) by promoting their SUMOylation, and aggravated neuroinflammation and neuronal apoptosis [97, 98]
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