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The following outline highlights genuine concerns that patients and clinicians must carefully consider

Lipid peroxidation is a marker of oxidate stress, and the product 4-hydroxy-2-nonenal (4HNE) is increased in the lung tissue of COPD patients, indicating the local production of ROS [24]

Glutathione can be supplemented orally, topically, or via inhalant

This research strengthens the advantages derived from dendrimers, such as enhanced structural adaptability, stability, and mucosal penetration, as well as improved drug loading efficiency and sustained drug release (Suthar et al., 2025)