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Cells acquire cysteine mainly by macrophage and lymphocyte uptake, and impaired immune responses are associated with a reduction in GSH concentration (Drge and Breitkreutz, 2000

A small sample (biopsy) of the ulcer may be taken in clinic and examined, to exclude cancer

It is known that CNS cultures involving serum can lead to reactive changes in CNS cells, especially astrocytes, as reported in previous studies comparing prospective astrocyte isolation (e.g., immunopanning or FACS-based isolation) to the classic culture and enrichment of astrocytes according to McCarthy and de Vellis (1980) (Fu et al., 2015

dEmden MC, Shaw JE, Jones GR, Cheung NW