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ERK1/2 regulates cell survival, differentiation, and proliferation
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Cell and animal studies suggest potential effects on collagen remodeling, but human clinical trials are sparse and inconclusive
Similarly, proteins and small-molecule antioxidants such as glutathione (GSH) are vulnerable to ROS, leading to impaired cellular redox buffering, mitochondrial dysfunction, and diminished contractile and neuronal function [39]
