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Moderate-to-high intensity physical exercise in patients with Alzheimer's disease: a randomized controlled trial

MYCN impacts the transcription of target genes by recruiting histone lysine acetyltransferases (KATs), which acetylate promoter regions to open the chromatin structure and favor gene expression 10,15,16

Ultimately, this exacerbates ROS generation, creating a self-reinforcing vicious cycle (66, 67)

Smith et al., 1984
