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Description
G.MiglioriG
Tf containing one or two ferric ions binds to transferrin receptor 1 (TfR1), forming a complex that enters the cell via receptor-mediated endocytosis and then enters the non-lysosomal acid compartment
Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner
G., Zurkirchen L., et al
