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MK-677 has a clearer regulatory history and is more explicitly recognized as a drug substance by regulators, which increases enforcement risk if misused in commercial products

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before development of HPLC, separation methods reported only total carotenoid content [29], while HPLC technique provided more details on each specific carotenoid level

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Nat Commun 7:13322 Baeten CI et al (2009) Prognostic role of vasculogenic mimicry in colorectal cancer

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