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NNMT is an enzyme that grabs nicotinamide and methylates it, turning it into a waste product called 1-MNA that gets cleared from the body

Health Canada has stated that unauthorized injectable peptides cannot lawfully be compounded for human use, and the FDA's December 2024 PCAC review recommended against permitting AOD-9604 in 503A compounding in the United States

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Semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2
