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Mild gastrointestinal symptoms (transient nausea, vomiting, abdominal cramps, and diarrhea) have been reported

Metformin-induced thyrotropin suppression is not associated with cardiac effects

In another study of 78 women aged 1840, a modest association was observed between endometriosis and increased levels of a marker of oxidative stress called thiobarbituric acid-reactive substances (Jackson 2005)
Intestinal hypoxia-inducible factor 2 regulates lactate levels to shape the gut microbiome and alter thermogenesis
