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Description
Major depressive disorder is characterized by an elevated Bacteroidetes/Firmicutes ratio ( Bacteroides and depletion of Blautia , Faecalibacterium , and Coprococcus , alongside increased abundance of Eggerthella and elevated levels of pro-inflammatory genera such as Escherichia ( 245)
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However, numerous studies document higher incidences of mitochondrial abnormalities in affected individuals
On the other hand, mitochondria-related mechanisms of apoptosis activation prevail over the antiapoptotic mechanisms in this disorder [16, 158, 199]
