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The two pathways diverge after the first two methylation events, facilitated by the uroporphyrinogen III methyltransferase, and re-join around the point of the final amidations
10.1016/j.jconrel.2016.08.035 [DOI] [PubMed] [Google Scholar] Xu C., Sun L., Ren F., Huang P., Tian Z., Cui J., et al
Where PDA works primarily through VEGFR2 and nitric oxide pathways, GHK-Cu works through copper-dependent enzyme activation and gene regulation
