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After screening for eligibility, a detailed information regarding the study will be provided focusing on the duration, collection of biological samples and the follow-up plan of the study

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There is evidence for a deceleration of overall protein turnover with aging (3034), which suggests that the supply of cysteine and glycine could be decreased

Statistical analysis For animal studies, sample sizes ( n = 5 per group, 3 in the tirzepatide-treated group) were determined based on prior in-house experience and previous studies using similar mouse models to ensure adequate power to detect biologically relevant effects