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It has long been recognized that LDL-C underestimates risk of ASCVD in the setting of hypertriglyceridemia (467)
Emphasis is placed on protecting-group selection, step economy, and preparative feasibility as discussed in peer-reviewed organic chemistry research
[DOI] [PMC free article] [PubMed] [Google Scholar] Babu, K
It decreases VLDL synthesis and secretion by a) reducing hepatic lipogenesis (synthesis of FA from acetyl CoA), b) increasing beta-oxidation of FA and c) inhibiting TG-synthesizing enzymes (e.g., DGAT)
