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No change in cytokine release (4 h after reactivation) was observed when the CD8 + T cells were incubated in 21% or 5% oxygen, but when reactivation was performed at 1% oxygen, levels akin to the tumor microenvironment or sites of infection, ML226-treated CD8 + T cells showed reduced secretion of interferon (IFNy), granzyme B and Fas ligand (FASL
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