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(2025) 10:e0054425

Albeit not significant, the mean values of tetranor-PGEM/tetranor-PGDM ratio of the patients with the severe phenotype (mean 5.9 4.9, median 4.9, range 2.213.9) was 1.8-fold higher than that of the healthy controls ( p = 0.050) and 0.95- and 0.82-fold lower than that of the patients with the mild and typical phenotypes, respectively, ( p = 0.855 and 0.407, respectively)

F = 0.8 fixed