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Although valuable to our understanding of the potential functional roles and regulation of these proteins in age-related cognitive decline, larger-scale approaches are needed to provide broad quantitative assessment of the hippocampal neuroproteome since cognitive decline is a complex phenomenon comprising both age-related and cognition-specific processes that are not entirely understood

The toxicity symptoms usually start with dizziness, nausea, vomiting, retrosternal burning, numbness and rapidly deteriorate to hypotension, shock, respiratory failure, arrhythmias, disseminated intravascular coagulation, hepatotoxicity, and renal failure

doi: 10.1007/s11783-019-1191-7 143 LiuQ.LiuY.DongF.SallachJ

Thyroid hyperplasia and nodular development can be induced by the use of rodent models and transgenic mice with mutations in genes such as Ras or TSH receptor mutations