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SARS-CoV-2-infected patients with COVID-19 disease show alterations in the glucoseinsulin axis leading to hyperglycemia, hyperinsulinemia and insulin resistance, increased oxidative/nitrosative stress, and significantly decreased vitamin D, thiols, total-antioxidant-capacity, GSH and selenium (Soto et al., 2022)

HSCs are also activated by increased attachment to the ECM, mediated by integrin/focal adhesion kinase signaling, suggesting a self-sustaining program of collagen deposition and HSC activation (197)

(PubMed) Woods KL, Fletcher S, Roffe C, Haider Y

Mood and anxiety regulation by nicotinic acetylcholine receptors: a potential pathway to modulate aggression and related behavioral states