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In ASD serotonin and IL-6 have been proposed as potential combined biomarkers since both present increased levels compared to control groups (Yang et al., 2015)

additionally, more research is required to investigate differences between NAD + modulators within different tissues, different models or pathologies, administration or exercise regimens, and how to successfully translate these findings to humans, while several clinical trials have already been conducted

Briefly, ALA is conceived as a biological antioxidant that is both water- and fat-soluble and is capable to neutralize ROS everywhere in the body, inside and outside the cells, and for this reason, ALA is being referred as the universal antioxidant [38,39,40]