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undertook a double blind RCT in which a population with degenerative orthopaedic alteration with neural compression were randomised to a treatment arm of either nucleosides and B12 combination of cytidine monophosphate disodium (CMP) 2.5 mg, uridine triphosphate trisodium (UTP) 1.5 mg and hydroxocobalamin 1000 g orally ( n = 200) or a B12 only regimen of hydroxocobalamin 1.0 mg orally ( n = 200)