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For instance, tumor cell-intrinsic effects may be at odds with effects on the tumor microenvironment, as is potentially the case for colon cancer, where DNA hypomethylation is observed in the cancerous colonic epithelia while the surrounding immune cells of these tumors exhibit DNA hypermethylation
doi: 10.1038/nature13148 44 GryzikMAspertiMDenardoAArosioPPoliM

Walker SE, Dufour A, Iazzetta J
