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Peroxisome proliferation-activated receptor-gamma (PPAR-) coactivator-1 (PGC-1) is the dominant regulator of mitochondrial biogenesis, regulated by upstream factor sirtuin 1 (SIRT1) partly, by changing the content and/or activity of transcription regulators such as PPAR//, estrogen-related receptor- (ERR), nuclear respiratory factor 1 (NRF1), and the mitochondrial transcription factor (TFAM), which regulates the replication and transcription of mitochondrial DNA (88)