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Finally, in most forms of cell death, there is the accumulation of oxygen free radicals, mitochondrial dysfunction, et al

In the study by Fukushi et al., it was demonstrated that LprG suppresses inflammation in macrophages by downregulating nitric oxide (NO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and pro-inflammatory cytokines through the nuclear factor B (NF-B), activator protein-1 (AP-1), and mitogen-activated protein kinase (MAPK) signaling pathways ( 2.1.2 LAM LAM is a type of arabinose carbohydrate found on the extracellular vesicle membranes of Mtb, accounting for about 15% of the weight of Mtb ( Additionally, due to the presence of 5-methylthio-D-xylose (MTX) sugar on LAM, as well as a D-mannose (Man) cap structure encoded and co-regulated by bacterial genes such as Rv1635c and Rv2181, LAM exhibits specific antioxidant properties (216)

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