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In contrast, nanoparticles with diameters ranging from 100 to 700 nm are favorable for nose-to-brain delivery, an alternative route that bypasses the BBB (Markova et al., 2022)

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The safety assessment is based on the independent safety profiles of each compound (GLP-1 medications through extensive FDA trials, BPC-157 through decades of preclinical research), their non-overlapping mechanisms, and growing clinical experience from physicians who prescribe both

"Development of Growth Hormone Releasing Peptides." Endocrine , 1998.