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Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements.[39] Depletion of liver glutathione levels (the site of glutathione storage) may be devastating to health

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The sections were dehydrated with 70% ethanol, 80% ethanol, and 95% ethanol for 2 min each, dehydrated with 100% ethanol, and sealed with neutral gum