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Treatment of A42-injected rats with an inhibitor of dipeptidylpeptidase-4, sitagliptin, together with quercetin, a flavonol from the flavonoid group of polyphenols, significantly diminished the level of A42 compared with either treatment alone but increased antioxidant protein levels (i.e., SOD, CAT) and the level of GSH and a diminution of histopathologically determined neuronal damage

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This autonomic imbalance often manifests as postural orthostatic tachycardia syndrome (POTS), where patients experience a rapid and uncomfortable increase in heart rate upon standing