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Quercetin has low skin permeability, and some drug formulations have been produced to increase its permeability for topical application, such as nanocapsules, nanoemulsion, microemulsions, and solidlipid nanoparticles (Nagula and Wairkar 2019)

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Consistently, given the close BPC 157/NO-system relations (see Chapter NO), these should be overseen with the evidence that the gasotransmitters can cross the cell membrane and act directly on molecules inside the cell [36], and thereby, particularly interacting with receptors on the plasma membrane of their target cells can be envisaged