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Hirsutosterols A-G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta

Mechanistically, the SAM derived from one carbon metabolism increases the promoter abundance of H3K27me3 of insulin-like growth factor 1 (IGF1), which in turn results in the inactivation of p38-dependent JAK-STAT1 axis and promotes the STAT6-mediated M2 polarization (69)

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