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High doses of vitamin B12 of up to 1,000 mcg are considered safe because the body will use the amount that it needs, and any excess will be flushed out through urine
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Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts, Chang CH, Tsai WC, Hsu YH, Pang JH, Molecules, 2014 Nov 19;19(11):1906619077

Individual neurochemistry varies significantly, and some people simply do not respond well to DSIP regardless of protocol optimization