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J Biol Chem (2008) 283(9):525866.10.1074/jbc.M707125200 92 WernigGGonnevilleJRCrowleyBJRodriguesMSReddyMMHudonHEet alThe Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

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The TGR inhibitor demonstrating greatest efficacy in treating infected mice, 2 , was also studied after oral administration: 2 (200 mg/kg p.o.) gave plasma concentrations of 0.71, 0.77, and 0.40 M at 30, 60, and 120 min, respectively (Supplementary Table 19)

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