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Peer review Peer review information Nature Catalysis thanks Mattheos Koffas, Bengt Mannervik, Boas Pucker, Dingguo Xu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

GSH depletion is driven through esterase catalyzed release of quinone methide intermediates carboxylic ester of B2C
The protective effect of NAC against oxidative stress can be attributed to the Nrf2 pathway, which increases GSH synthesis [71,72]

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