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Interestingly, this occurred in male rodents only and blockade of this stress response ameliorated any behavioral abnormalities associated with maternal immune activation, suggesting a sex-specific effect of maternal immune activation on neuroinflammation and neurodevelopment (Kalish et al., 2021)
The brain consists of various cell types, including neurons and glial cells (astrocytes, microglia, and oligodendrocytes), each playing a crucial role in maintaining brain function
There are conflicting data on the relationship between pre-existing anti-AAV nAb titers and vector transduction efficiency
