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87 In the UC rat model, NaHS can promote autophagy by regulating the levels of autophagy-related proteins, including increasing the LC3-II/LC3-I ratio and decreasing the level of p62

The neuroprotective effects come through multiple pathways: inhibition of nitric oxide synthesis under ischemic conditions, antioxidant activity, protection against glutamate neurotoxicity, and mitochondrial stabilization under calcium dysregulation

We observed that CBD attenuated the hypoxia-induced increase in free iron content (Fig

3.5 Inhibiting the TCA Cycle by Depleting Glutamine, -Ketoglutarate, and Asparagine One of the earlier means of suppressing glutamine metabolism arose from reducing the amount of available glutamine itself