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Most of the current recommendations and guidelines over the years have thus been based on subsequent retrospective single center experience or data from large surveillance databases run by the pharmaceutical industry as the best surrogates for efficacy and safety of GH therapy of adult GH deficiency (14)

Consistency of timing, day to day, also matters more than the exact clock hour, because the axis responds to a regular rhythm

Autophagy 2025 May;21(5):934-956
