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While evidence shows potential, rigorous investigations are needed to definitively establish its mechanisms and potential therapeutic applications Table 2 [46]

Not alleviated by rest or adequate sleep

Acknowledgments Figures were created using BioRender.com (accessed on 30 October 2022)

S2C), and immunofluorescence analysis confirmed the presence of differentiated intestinal cell types, including Muc2+ goblet cells, Lyz+ paneth cells, Chga+ enteroendocrine cells, Dclk1+ tuft cells, and Fabl1+/Alpi+ absorptive enterocytes (Figs
