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This phenomenon may be specifically attributed to Bacteroides fragilis enrichment, which compromises intestinal barrier integrity through mucin degradation-mediated disruption of the mucosal layer (Ji et al., 2023

The zinc chelator N,N,N,N-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) exacerbates oxidative damage that originally depleted intracellular free zinc and decreased Nrf2 expression and transcription [107]

After this interaction, glutathione is transformed from its reduced form to its oxidized one

[DOI] [PubMed] [Google Scholar] 101.Takayama K., Nakano M., Zinner K., Vidigal C.C., Durn N., Shimizu Y., Cilento G