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50 Studies have shown that in the mouse model of knockedout SLC38A3 activity, associated perivascular astrocytes showed swelling and a decrease in the apparent diffusion coefficient

A second Yap1-regulated group included genes encoding proteins with aldo-ketoreductase and oxidoreductase activities (ADH6, GRE2, SCS7 and OYE2).29 Interestingly, the loss of CgYap1 had no impact on virulence in both primary mouse macrophages or in a murine model of systemic infection.4,29 It is possible that either the genes controlled by CgYap1 are dispensable to survive within the host or there are redundant mechanisms that compensate the lack of the genes controlled by this transcription factor

Tannins can form complexes with metal ions, thereby preventing the Fenton reaction and reducing ROS generation [217]

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