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Kunyuan Wanghe, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Experimental Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The tar phase of cigarette smoke contains long-lived radicals, while the gas phase contains short-lived radicals such as nitric oxide and superoxide

Four of these SODs are copper-zinc (Cu-Zn)-dependent, namely the cytoplasmic Sod1 and the cell surface Sod4, Sod5, and Sod6

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