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Pizzagalli et al

Furthermore, they exhibited degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy

7A, B), suggesting both genes were regulated by DMF in an NRF2-dependent but not 5hmC-dependent regulatory manners

Although AP-SNPs have shown great potential, further research and evaluation are needed to assess their potential biotoxicity and environmental impact to ensure their safe and effective clinical application
