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3.1.1 Nuclear receptor signaling disruption 3.1.1.1 Androgen receptor antagonism Bisphenol A exhibits androgenic antagonism, functioning as a competitive antagonist that blocks androgen receptor binding and subsequently reduces ARE-mediated gene transcription, with documented effects on androgen-dependent gene expression
In the pivotal SURMOUNT-1 clinical trial, participants taking the highest dose of tirzepatide achieved an average body weight reduction of up to 22.5% over 72 weeks
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Gut-Brain Axis Support It may influence neurochemical pathways, enhancing communication between the gut and central nervous system
