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Alpha-lipoic acid (ALA) seems to be an important first-line pathogenesis-directed agent, given that it is a direct and indirect antioxidant that works with a strategy targeted directly against reactive oxygen species and indirectly in favor of endogenous antioxidant capacity for improving DPN conditions

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Diarrhea and constipation also occur in significant percentages of the user population

Dynamics of cytochrome P4502E1 activity in man: Induction by ethanol and disappearance during withdrawal phase
