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Gene expression analysis in human tissue indicated that ucn2 is mostly produced in the brown fat, skeletal muscle, kidney, and smooth muscle, while ucn3 is produced mostly in the pancreas and smooth muscle (Fig
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doi: 10.1016/j.ijpharm.2006.02.044
Subsequently, 3-hydroxy-methylglutaryl-CoA lyase (HMGCL) cleaves HMG-CoA in an irreversible reaction into acetyl-CoA and the first ketone body, AcAc
